Publications

2022

Reprogramming the piRNA pathway for multiplexed and transgenerational gene silencing in C. elegans. Priyadarshini M, Ni JZ, Vargas-Velazquez AM, Gu SG, Frøkjær-Jensen C. Nature Methods. (2022) Pubmed.

Modular safe-harbor transgene insertion (MosTI) for targeted single-copy and extrachromosomal array integration in C. elegans. El Mouridi S, Alkhaldi F, Frøkjær-Jensen C. G3 (Bethesda). (2022) Pubmed.

Target-dependent suppression of siRNA production modulates the levels of endogenous siRNAs in C. elegans germline. Gajic Z, Kaur D, Ni J, Zhu Z, Zhebrun A, Gajic M, Kim M, Hong J, Priyadarshini M, Frøkjær-Jensen C, Gu S. Development. (2022) Pubmed.

Targeted and Random Transposon-Assisted Single-Copy Transgene Insertion in C. elegans. El Mouridi S, Frøkjær-Jensen C. Methods Mol Biol. (2022) Pubmed.

2021

A histamine-gated channel is an efficient negative selection marker for C. elegans transgenesis. El Mouridi S, AlHarbi S, Frøkjær-Jensen C. MicroPublication Biology. (2021) Pubmed.

A single-nucleotide change underlies the genetic assimilation of a plastic trait. Vigne P, Gimond C, Ferrari C, Vielle A, Hallin J, Pino-Querido A, El Mouridi S, Mignerot L, Frøkjær-Jensen C, Boulin T, Teotónio H, Braendle C. Science Advances. (2021) Pubmed.

2020

Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans. Aljohani MD, El Mouridi S, Priyadarshini M, Vargas-Velazquez AM, Frøkjær-Jensen C. Nature Communications. (2020) Pubmed.

SapTrap Assembly of Caenorhabditis elegans MosSCI Transgene Vectors. Fan X, De Henau S, Feinstein J, Miller SI, Han B, Frøkjær-Jensen C, Griffin EE. G3 (Bethesda). (2020) Pubmed.

Characterizing a strong pan-muscular promoter (Pmlc-1) as a fluorescent co-injection marker to select for single-copy insertions. El Mouridi S, Peng Y, Frøkjær-Jensen C. MicroPublication Biology. (2020) Pubmed.

2019

Assessment and Maintenance of Unigametic Germline Inheritance for C. elegans. Artiles KL, Fire AZ, Frøkjær-Jensen C. Developmental Cell. (2019) Pubmed.

The Caenorhabditis elegans Transgenic Toolbox. Nance J, Frøkjær-Jensen C. Genetics. (2019) Pubmed.

A balance between silencing foreign DNA and protecting self in Caenorhabditis elegans. Frøkjær-Jensen C. Current Opinion in Systems Biology. (2019) Link.

2016

An Abundant Class of Non-coding DNA Can Prevent Stochastic Gene Silencing in the C. elegans Germline. Frøkjær-Jensen C, Jain N, Hansen L, Davis MW, Li Y, Zhao D, Rebora K, Millet JRM, Liu X, Kim SK, Dupuy D, Jorgensen EM, Fire AZ. Cell. (2016) Pubmed.

2015

Transposon-Assisted Genetic Engineering with Mos1-Mediated Single-Copy Insertion (MosSCI). Frøkjær-Jensen C. Methods Mol Biol. (2015) Pubmed.

2014

Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon. Frøkjær-Jensen C, Davis MW, Sarov M, Taylor J, Flibotte S, LaBella M, Pozniakovsky A, Moerman DG, Jorgensen EM. Nature Methods. (2014) Pubmed.

2013

Exciting prospects for precise engineering of Caenorhabditis elegans genomes with CRISPR/Cas9. Frøkjær-Jensen C. Genetics. (2013) Pubmed.

2012

Improved Mos1-mediated transgenesis in C. elegans. Frøkjær-Jensen C, Davis MW, Ailion M, Jorgensen EM. Nature Methods. (2012) Pubmed.

2011

The alpha1 subunit EGL-19, the alpha2/delta subunit UNC-36, and the beta subunit CCB-1 underlie voltage-dependent calcium currents in Caenorhabditis elegans striated muscle. Lainé V, Frøkjær-Jensen C, Couchoux H, Jospin M. J Biological Chemistry. (2011) Pubmed.

MosSCI and gateway compatible plasmid toolkit for constitutive and inducible expression of transgenes in the C. elegans germline. Zeiser E, Frøkjær-Jensen C, Jorgensen E, Ahringer J. PLoS One. (2011) Pubmed.

2010

Targeted gene deletions in C. elegans using transposon excision. Frøkjær-Jensen C, Davis MW, Hollopeter G, Taylor J, Harris TW, Nix P, Lofgren R, Prestgard-Duke M, Bastiani M, Moerman DG, Jorgensen EM. Nature Methods. (2010). Pubmed.

2009

Calcium: an insignificant thing. Frøkjær-Jensen C, Jorgensen EM. Nature Neuroscience. (2009) Pubmed.

2008

Single-copy insertion of transgenes in Caenorhabditis elegans. Frøkjær-Jensen C, Davis MW, Hopkins CE, Newman BJ, Thummel JM, Olesen SP, Grunnet M, Jorgensen EM. Nature Genetics. (2008). Pubmed.

Ammonium-acetate is sensed by gustatory and olfactory neurons in Caenorhabditis elegans. Frøkjær-Jensen C, Ailion M, Lockery SR. PLoS One. (2008) Pubmed.

2007

Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment. Rasmussen HB, Frøkjær-Jensen C, Jensen CS, Jensen HS, Jørgensen NK, Misonou H, Trimmer JS, Olesen SP, Schmitt N. Journal of Cell Science. (2007) Pubmed.

2006

Effects of voltage-gated calcium channel subunit genes on calcium influx in cultured C. elegans mechanosensory neurons. Frøkjær-Jensen C, Kindt KS, Kerr RA, Suzuki H, Melnik-Martinez K, Gerstbreih B, Driscol M, Schafer WR. J Neurobiology. (2006) Pubmed.

Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases. Ortiz CO, Etchberger JF, Posy SL, Frøkjær-Jensen C, Lockery S, Honig B, Hobert O. Genetics. (2006). Pubmed.

2004

MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode. Chang S, Johnston RJ Jr, Frøkjær-Jensen C, Lockery S, Hobert O. Nature. (2004) Pubmed.

The neurotoxic MEC-4(d) DEG/ENaC sodium channel conducts calcium: implications for necrosis initiation. Bianchi L, Gerstbrein B, Frøkjær-Jensen C, Royal DC, Mukherjee G, Royal MA, Xue J, Schafer WR, Driscoll M. Nature Neuroscience. (2004). Pubmed.

2003

In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation. Suzuki H, Kerr R, Bianchi L, Frøkjær-Jensen C, Slone D, Xue J, Gerstbrein B, Driscoll M, Schafer WR. Neuron. (2003) Pubmed.

2001

Pharmacological modulation of SK3 channels. Grunnet M, Jespersen T, Angelo K, Frøkjær-Jensen C, Klaerke DA, Olesen SP, Jensen BS. Neuropharmacology. (2001) Pubmed.